It depends on the individual. The 16-hour patches work just as well as the 24 hour ones. Some people prefer the 16-hour patches because they only supply the body with nicotine during their waking hours when they would usually smoke. This also means there is less chance of sleep disruption using the 16-hour patches. Those who prefer the 24-hour patches often do so to help them overcome their strong craving for a cigarette in the morning. If you are someone who craves a cigarette within five minutes of waking up then this is an indicator of high level of nicotine dependence.